1. Saccharin has been used in the United States as a sugar substitute since 1885, primarily in food and beverage and in personal care products such as toothpaste and mouthwash. 2. End users in the food and beverage markets are primarily soft-drink manufactures and manufactures of table-top sweetener packets for restaurants, airlines, and other firms serving beverages to the public. 3. Saccharin is also used in pharmaceuticals, animal feed, tobacco, and food mixes. It is also used as an additive in adhesives and in metalworking fluids to facilitate electroplating.